C-Change is comprised of the nation's key cancer leaders from government, business, and nonprofit sectors. These cancer leaders share the vision of a future where cancer is prevented, detected early, and cured or is managed successfully as a chronic illness.

One of the underlying principles of C-Change is to leverage the leadership and expertise of all sectors of society to eliminate cancer as a major public health problem at the earliest possible time.

C-Change is both a forum and a catalyst for identifying issues and major challenges facing the cancer community and for initiating collaborative actions to complement the efforts of individual C-Change Members.

Former President George Bush and former First Lady Barbara Bush are Co-chairs of C-Change; Senator Dianne Feinstein serves as Vice Chair. Currently, there are about 130 C-Change participants, all of whom are central figures from the public, private, and nonprofit sectors.

C-Change was accepted as a UICC member in 2005